You must select and set up your audio hardware in the Studio Setup dialog before you can use it.
You have selected a driver for your audio hardware.
Plug-in Administration In Cubase 9 (and Higher)
Procedure
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Select Studio > Studio Setup.
In the Devices list, select your audio hardware driver.
Do one of the following to open the control panel for your audio hardware:
On Windows, click Control Panel.
On macOS, click Open Config App.
This button is available only for some hardware products. If it is not available in your setup, refer to the documentation of your audio hardware.
Note
The control panel is provided by the manufacturer of your audio hardware and is different for each audio interface brand and model. However, control panels for the Generic Low Latency ASIO Driver (Windows only) are provided by Steinberg.
Set up your audio hardware as recommended by the manufacturer.